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Acknowledgements We extend our gratitude to the general practitioners who participated in MedicineInsight and to the patients who contributed their data to the dataset

Side effects are usually mild at normal doses

Step 4: Give it time

In accordance with this, it has been estimated that the steady-state concentration of superoxide in the mitochondrial matrix is 5- to 10- fold higher than in the cytosol (Orrenius et al., 2007)