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GLP-1RAs may improve BMD, bone strength and bone microstructure and reversed GIOP, primarily through slow down of bone resorption and promotion of bone formation and osteogenic differentiation

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Rapid weight loss has been a hallmark of these medications, which work, in part, by making users feel full earlier by activating receptors of hormones secreted from the intestine (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) to reduce appetite and food intake