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When taken with tacrolimus, they can cause dangerously high blood concentrations of the drug

65 TerataniT.TomitaK.SuzukiT.FuruhashiH.IrieR.HidaS.et al (2017)

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However, in the posterior cortex, CAT activity was reduced in the VPA+LipRSV group compared to the VPA group, indicating that LipRSV treatment may have negatively modulated the enzymes expression or activity, either by attenuating oxidative stress and thus reducing enzymatic defense needs, or through a possible pro-oxidant effect dependent on the region and experimental conditions

let a refrigerated vial sit at room temperature for 510 minutes