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We noted that the treatment of animals with doxycycline, which was required to induce GLR1 and FDH3 overexpression, resulted in increased outcome score for infection with the wild type C

coli , MRSA, and multidrug-resistant A

The challenge has been to minimise and balance the pharmacology to select a combination that maximises the benefit without risk of irreversible toxicity, as historically experienced in co-therapy with fenfluramine and phentermine

We focus on understanding how pathogens persist outside the host, move between environmental reservoirs and production settings, and acquire traits that influence persistence and survival