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The 4 to 8 mg jump is the largest absolute increase in the standard protocol and carries the highest side effect risk
The drug was used in a double-blind, randomised, placebo-controlled trial including 526 adult participants with type 2 diabetes across China, India, Japan, Mexico, and the United States
These modifications enable investigation of prolonged GLP-1 receptor interactions in model systems, which would not be possible with native GLP-1 due to its rapid degradation in the body
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