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Since 2021, semaglutide has also been approved specifically for chronic weight management in adults with a body mass index (BMI) of 27 or greater, those who have at least one weight-related condition, such as high blood pressure, type 2 diabetes, or high cholesterol
The gradual dose escalation schedule is specifically designed to minimise these moving up doses too quickly is the main reason gastrointestinal side effects become difficult to manage
Some patients might then continue with weekly injections at 100 mg as maintenance
The D-Phe stereochemistry and Nle substitution were specifically selected to resist enzymatic proteolysis, as established in the precursor work (Sawyer 1980, PMID 6777774)
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