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Stress management techniques warrant consideration, as chronic stress activates the hypothalamic-pituitary-adrenal axis and can increase cortisol levels, which may intensify food cravings, particularly for high-calorie comfort foods

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Additionally, alcohol-induced dehydration impairs renal filtration of THC metabolites

Furthermore, AMPK inhibitor compound C abolished the metformin-mediated upregulation of GLP-1R level and PKA phosphorylation

The preliminarily inhibitory potency among them in cell level was evaluated that they are nicely according to the results in silico and in enzymatic assay (data not shown)