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Another way that semaglutide helps with weight loss is by increasing energy expenditure, or the number of calories burned by the body
However, the half-life of natural GLP-1 in plasma is less than 2 min because it is rapidly enzymatically degraded by DPP-IV
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Tirzepatide bypasses this issue by heavily engaging GIP receptors, which are encoded by a separate gene (GIPR)
This decision is based on the strong obesity data obtained for semaglutide and AM833 that, in aggregate, have raised the innovation bar for future Novo Nordisk obesity care and we've, therefore, prioritized our resources accordingly to achieve the best possible patient outcomes and product benefit risk profile
