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The precursor literature includes human pharmacokinetic work
Watkins PB, Kaplowitz N, Slattery JT, Colonese CR, Colucci SV, Stewart PW, Harris SC: Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily
These combinations are largely untested in clinical trials
This "leftover" unabsorbed material in the gut can contribute to the bloating and gas that make some users feel sick
Quinine is an extremely toxic agent in overdose, with vision loss as a common outcome
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