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So they really believe that worked and we did a whole show on that
[5] [6] The STEP trials evaluating semaglutide for weight management showed similar patterns, with gastrointestinal adverse events being the primary reason for treatment discontinuation in a small percentage of participants
These mixed results happen because semaglutide influences metabolism, hormone levels, and emotional well-being
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In the central nervous system (CNS), GLP-1 and GLP-1R agonists are diffused into the cerebrospinal fluid (CSF) and the brain as demonstrated in rodent models (Wang et al., 2015), and increased GLP-1 concentration in the brain is thought to influence brain function in the hippocampus (McClean et al., 2010
