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It is known that several cytokines, such as IL-6, IL-10, and TGF-, which activate STAT3 signaling, are potent inducers of the differentiation and activation of MDSCs [97]

The compounds effects on new blood vessel formation have been documented in research papers

doi: 10.1038/nature21363 365 CahillGFJr

More recent clinical work on combined GHRH/GHS secretagogue treatment found measurable increases in serum IGF-1, reinforcing why researchers pair both mechanisms in a single spray formulation (Sigalos et al., Am J Mens Health, 2017)