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For receptor attribution studies: MC1R-selective antagonists to isolate melanogenesis biology, MC4R-selective antagonists to isolate pro-sexual and anorectic biology, and MT-1 parallel groups to characterise the additional central effects produced by cyclisation

4g and Supplementary Table 16)

Although a trend toward reduced HCC risk was observed, this failed to achieve statistical significance in the overall analysis (IRR: 0.82, 95%CI: 0.61-1.11, P = 0.189), possibly reflecting insufficient follow-up duration to capture the full impact on hepatocarcinogenesis

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