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Whilst many symptoms improve with appropriate B12 treatment, not all resolve completely, especially if neurological damage was severe or prolonged before treatment commenced

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

Animal experiments have not shown significant adverse effects at therapeutic dosages