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Davies M et al (2021) Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

Individual calorie requirements on GLP-1 therapy depend on numerous physiological and lifestyle factors that must be considered for personalised nutritional planning

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This dose-response relationship across receptor activation suggests that the more pathways you stimulate, the higher the likelihood of neurological side effects including skin sensitivity

It's a relatively high amount for a supplement to have, but it shouldn't be a problem for most people since the maximum per-day allowance for adults is 400mcg.34 That said, you may want to avoid Doctor's Best Glutathione + Milk Thistle if you take another supplement that includes selenium or eat a lot of selenium-rich foods (e.g., Brazil nuts, tuna)