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Immediate Mitochondrial and Neurological Oxidative Protection Hydrogen water offers unique advantages in providing immediate protection to cellular regions where GR activity may be naturally limited or insufficient: Blood-brain barrier penetration : While GR is expressed in brain tissue, hydrogen molecules readily cross the blood-brain barrier, providing antioxidant protection regardless of endogenous GR status
Concerning food choices, a low-fat diet with meals prepared by boiling, baking, or grilling is crucial for a better management of GI AEs [15]
Phase 2 trials have included striatal binding of dopamine transporter in the secondary outcome measures (NCT03100149, NCT03318523, Table 2), which would be of interest to correlate with the clinical outcome measures, and the biofluid-measured alterations to improve understanding of the drug action mechanism
Pre-treatment with 2-APB, a well-known SOCE modulator, attenuated these responses, preserving neuronal integrity and decreasing microglial cell activation