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Once bound, the glutathione carries it to the urine and it is then excreted
A spokesperson for Eli Lilly previously said in a statement: "Retatrutide is an investigational, once-weekly, triple hormone receptor agonist, which activates the body's receptors for glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon
Other known side effects include dehydration which can lead to kidney dysfunction (0.3%) but this is mostly seen in patients with pre-existing kidney disease
The more aggressive approach is to start creatine immediately alongside tirzepatide, or to continue existing creatine supplementation when beginning the medication
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