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these reactions might entail a molecular rearrangement possibly involving the addition of water to the keto group in the cyclopentone ring, that result in the introduction of a hydroxyl group into the AFB 1 structure
It is likely due to rapid weight loss, other factors, or a combination
152 Moreover, the decreased permeability of the brain-blood barrier (BBB) to leptin and impaired leptin signal transduction in neurons will lead to leptin resistance in obesity
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57 (2), R93R108
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