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In one, researchers found that ipamorelin administration could counteract the skeletal muscle catabolism induced by glucocorticoids [4]
By contrast, real-world persistence drops off a cliff fairly early on
Patients who are obese or overweight and have at least one weight-related medical problem should consider it
However: Bioavailability is still significantly lower than injection (estimated 5-25%) Absorption is highly variable based on saliva production, food timing, and individual anatomy Higher doses are needed to compensate for lower absorption, increasing cost No clinical trials have validated sublingual CJC-1295/Ipamorelin dosing For patients who absolutely can't tolerate injections, sublingual may be worth discussing with your physician, but expectations should be adjusted accordingly
GLP-1s appear generally safe for people with RA who are taking them for other conditions, but more targeted research is needed
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