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The affinity of PF-06882961 (K i = 80 nM) measured using this new radioligand was 4.5-fold more potent and more consistent with its cAMP potency, whereas the clinical peptides had similar affinities using both radioligands (Table S6)
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That prior study found the simultaneous rise in GLP-1, cholecystokinin, and peptide YY tracked normal post-meal signaling [1]
![Cardiovascular disease continuum-GLP-1 action. Adapted from [46]](https://www.researchgate.net/publication/357072789/figure/fig1/AS:1146405179654167@1650335702879/Cardiovascular-disease-continuum-GLP-1-action-Adapted-from-46.png)
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