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Tirzepatide represents a dual agonist, targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, which may explain its enhanced efficacy in clinical trials
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Beta cell apoptosis, quantified by co-staining for TUNEL and the beta cell marker NKX6.1, was highest in new-onset mice, and approximately doubled compared with 12-week-old mice
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