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Glutamate is generated by extra- and intracellular glutaminases Glutaminolysis as illustrated in Figure 2 is associated with the increased expression of both the extrinsic cell membrane phosphate independent glutaminase/gamma glutamyltransferase/gamma glutamyltranspeptidase (PIG, GGT, GGTP) which generates extracellular glutamate [2,12] and intracellular phosphate dependent glutaminases, Phosphate dependent glutaminases (PDG,GLS1 and GAC, [13,14]) which generates glutamate cytosolically [2,13]
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This analysis also echoes the researchers comment that the drug has never been tested in humans and would require careful considerations of safety
Care Med ., 2006 , 174 , 530
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