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None of this means resM is worthless

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P53 phosphorylation at Ser15 enhances the affinity of both FOXO4 and FOXO4-DRI for p53 TAD2 explaining the preferential engagement of FOXO4-DRI with the hyperphosphorylated p53 characteristic of senescent cells

The good news is that this reaction is almost always a matter of chemistry and technique rather than a sign that anything has gone wrong

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