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For instance, induction of iNOS in microglia leads to a decrease in cellular GSH level, whereas, under comparable conditions, the GSH status of astrocytes remains largely unaffected ( - exposure (Makar et al., 1994)
[4] Liraglutide has been studied most extensively in this context, with observational studies showing improvements in both weight and metabolic parameters
In summary, GLP-1 RAs represent a promising therapeutic option for obese patients with HFpEF, but their large-scale adoption will require further evidence of efficacy, safety, and long-term benefits through rigorous and well-designed clinical trials
The affinity of hyperphosphorylation of tau protein to microtubules decreased, and hyperphosphorylated tau protein can no longer perform the function of maintaining the structure of the neurons, which slows the axonal transport (30)
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