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Meanwhile, PD1-NPs are generated by combining polyethylene glycol-poly(-caprolactone) (PEG-PCL) nanoparticles with nivolumab, which can target PD1-overexpressing tumor-infiltrating lymphocytes and reverse the exhaustion of PD1+CD8+ TILs when used in combination with the epigenetic drug 5-aza-2-deoxycytidine (DAC), improve T cell responses and enhance the efficacy of immune checkpoint blockade therapy (176)

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