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Collectively, these findings suggest that composite dietary fiber may alleviate obesity-induced muscle atrophy through structural and functional remodeling of the gut microbiota, potentially by enriching beneficial taxa and inhibiting harmful ones, thereby contributing to the restoration of myometabolic homeostasis

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These precedents highlight the need for indication-specific risk assessment and careful differentiation between mechanism-based toxicity and species-specific artifacts

For glucose-stimulated insulin secretion testing, the mice were fasted for 4 h before being challenged with intraperitoneal injections of 1.75 g kg 1 of glucose dissolved in isotonic saline