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The Medicines and Healthcare products Regulatory Agency (MHRA) and the Summary of Product Characteristics (SmPC) for both medications do not list either treatment as a contraindication for the other
Glucagon receptor agonism triggers pro-emetic signaling in the area postrema of the brainstem and increases intestinal motility through direct smooth muscle stimulation (PMC12992036)
However, some patients have anecdotally reported experiencing hot flushes or similar vasomotor symptoms whilst taking semaglutide, prompting questions about a potential connection
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Although there are many ongoing large CVD outcome trials of GLP-1 RA treatment (Table 1), more simultaneous investigation of the causal relationship between GLP-1 RA administration and useful surrogate measures of CVD, including carotid IMT, would help us understand the potential mechanisms through which GLP-1 RAs may result in favorable cardiovascular outcomes in patients with T2D
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