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(3) Analyze the binding modes of inhibitors, examine the interactions that facilitate inhibitor binding, and identify key binding residues or regions of the inhibitors

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Primarily, given that our conclusions are derived from a small sample size and observational study utilizing an animal model, these results need to be further verified in the population with pressure overload by large-sample prospective randomized controlled trial

Digestive enzymes are generally well-tolerated, but people with allergies to a specific enzyme source, certain medical conditions, or who take medications such as blood-thinners or diabetes drugs may need to avoid specific enzymes

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